Endure Rather Than Resist if You Want to Age Better
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Endure Rather Than Resist if You Want to Age Better

News Staff — Oxford University Press via Scimex
Nov 30, 2018

The proof is in your telomeres.

(Germany) -- Researchers have discovered evidence that endurance exercise, such as running, swimming, cross-country skiing and cycling, will help you age better than resistance exercise, which involves strength training with weights.

In a study published in the European Heart Journal, researchers in Germany looked at the effects of three types of exercise – endurance training, high intensity interval training and resistance training – on the way cells in the human body age, and they found that endurance and high intensity training both slowed or even reversed cellular aging, but that resistance training did not.

Our DNA is organized into chromosomes in all the cells in our bodies. At the end of each chromosome is a repetitive DNA sequence, called a telomere, that caps the chromosome and protects its ends from deteriorating. As we grow older, the telomeres shorten and this is an important molecular mechanism for cell aging, which eventually leads to cell death when the telomere are no longer able to protect the chromosomal DNA. The process of telomere shortening is regulated by several proteins. Among them is the enzyme telomerase that is able to counteract the shortening process and can even add length to the telomeres.

The researchers led by Professor Ulrich Laufs, of Leipzig University, Germany, enrolled 266 young, healthy but previously inactive volunteers and randomized them to six months of endurance training (continuous running), high intensity interval training (warm-up, followed by four bouts of high intensity running alternating with slower running, and then a final cool down of slower running), resistance training (circuit training on eight machines, including back extension, crunch, pulldown, seated rowing, seated leg curl and extension, seated chest press and lying leg press), or to an unchanged lifestyle (the control group).

The participants who were randomized to the three forms of exercise undertook three 45-minutes sessions a week, and a total of 124 completed the study. The researchers analyzed telomere length and telomerase activity in white blood cells in blood taken from the volunteers at the start of the study, and two to seven days after the final bout of exercise six months later.

Prof Laufs said: “Our main finding is that, compared to the start of the study and the control group, in volunteers who did endurance and high intensity training, telomerase activity and telomere length increased, which are both important for cellular aging, regenerative capacity and thus, healthy aging. Interestingly, resistance training did not exert these effects.”

Telomerase activity was increased two- to three-fold and telomere length was increased significantly in the endurance and high intensity training groups compared to the resistance and control groups.

“The study identifies a mechanism by which endurance training – but not resistance training – improves healthy aging. It may help to design future studies on this important topic by using telomere length as indicator of ‘biological age’ in future intervention studies,” said Prof. Laufs.

Co-author of the study, Dr. Christian Werner, of Saarland University, Germany, said: “The study has several implications: Our data support the European Society of Cardiology’s current guideline recommendations that resistance exercise should be complementary to endurance training rather than a substitute. The data identify telomerase activity and telomere length as sensitive ways to measure at cell level the effects of different forms of exercise. Using these measurements to guide training recommendations for individuals may improve both adherence to and efficacy of exercise training programs in preventing cardiovascular disease.”

Previous research has shown that longer telomeres and increased telomerase activity are associated with healthy aging. However, this is the first prospective, randomized controlled study of the effects of different forms of exercise on these two measurements of cellular aging.

Prof. Laufs said: “Physical exercise is widely recommended. However, prospective randomized controlled training studies are very rare because they require a great effort and there are no funding sources from industry. The numbers of participants in our study may appear small compared to large drug trials, however, to the best of our knowledge, this is the largest randomized study comparing well defined training modalities with a control group and with a long duration of six months. We hope that our project will stimulate confirmation and further studies in this field.”

A possible mechanism that might explain why endurance and high intensity training could increase telomere length and telomerase activity is that these types of exercise affect levels of nitric oxide in the blood vessels, contributing to the changes in the cells.

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