Red Sea Fungus Could Provide New, Better Epilepsy Drug
Amazing Health Advances Subscribe to Amazing Health Advances
An AHA Advertisement

To receive daily emails from Amazing Health Advances to your inbox CLICK HERE

Red Sea Fungus Could Provide New, Better Epilepsy Drug

News Staff — American Chemical Society
May 14, 2018

To find new leads, researchers have now turned to the sea -- a source of unique natural products that have been largely untapped for prospective drugs.

(Israel) — New treatments for epilepsy are sorely needed because current medications don't work for many people with the disease. To find new leads, researchers have now turned to the sea -- a source of unique natural products that have been largely untapped for prospective drugs. The scientists report in the journal ACS Chemical Neuroscience that two metabolites produced by a fungus from the Red Sea look promising. (Photo Credit: Flickr)

The term "epilepsy" covers a spectrum of brain disorders with symptoms ranging from mildly odd sensations to seizures, loss of consciousness and death. Worldwide, the condition affects 50 million people, according to the World Health Organization. Current treatments work in only about 70 percent of those who try them. To identify some new options, Marcel Jaspars, Peter A. M. de Witte and colleagues teamed up in an international collaboration called the EU PharmSea project that aimed to discover novel compounds from marine microorganisms in some of the deepest, coldest and hottest places on Earth. 

According to the researchers, this study was the first-ever systematic large-scale screen of marine-derived natural products for potential anti-seizure drugs. Initial tests of a variety of these compounds revealed that two γ-lactams produced by the Red Sea fungus Aspergillus fumigatus reduced the number and length of seizures in zebrafish, a model organism they used for high-volume screening of compounds. The researchers then showed that these natural substances, known as pseurotin A2 and azaspirofuran A, also shortened seizures in a mouse model of epilepsy. The scientists recommend further investigation of these metabolites to explore their biomolecular targets and to design more potent analogs.

American Chemical Society

Click Here For More Information


 

 

 

 





Amazing Health Advances