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The Thyroid Gland and "Seasonal Rhythms"
(New Rochelle, NY) — Researchers now have a better understanding of the role that thyroid hormones, the tissues that produce them, and the biochemical pathways on which they act have in driving seasonal reproduction in some mammals, and how this new information may help explain seasonal changes in metabolism and mood that affect humans. (Photo Credit: Mary Ann Liebert, Inc., publishers)
Co-authors Tomoya Nakayama and Takashi Yoshimura, Nagoya University and National Institute for Basic Biology, Okazaki, Japan explore the significance and implications of the data derived from the most recent genomic and molecular studies of animals that breed seasonally, such as the Japanese quail. The researchers examine the relationship between length of daylight, the secretion of thyrotropin (TSH) from the pituitary gland, and gonadal growth in animals. They discuss the value of comparative studies in various mammals, in which molecules such as TSH have been conserved across evolution. These studies may help shed light on the mechanisms underlying seasonal depression-like symptoms and weight gain in humans.
"Through a series of very elegant studies, Dr. Yoshimura's group has discovered that T3 … regulates gonadotropin-releasing hormone (GnRH) secretion in a seasonal fashion," says Peter A. Kopp, MD, Editor-in-Chief of Thyroid and Professor of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
To read this report in its entirety, click here.
Mary Ann Liebert, Inc./Genetic Engineering News